Association between insufficient physical activity and the risk of cognitive impairment in middle-aged and elderly people in rural China
Objective:To investigate the association between insufficient physical activity and cognitive impairment in middle-aged and elderly people,aged 45 years or older,in rural China based on data from the nationally representative large-scale longitudinal study.Methods:The data from China Health and Retirement Longitudinal Study(CHARLS)in 2011,2013,2015,2018,and 2020 were used for analysis.According to Physical Activity Guidelines for Chinese(2021),the level of physical activity was classified into insufficient physical activity and sufficient physical activity.Cognitive function was measured based on the four dimensions of orienta-tion,computation,memory,and drawing,and cognitive impairment was defined as a total score of at least 1 standard deviation(SD)below the age standard.The incidence rate of cognitive impairment was compared between the populations with different levels of physical activity,and the Cox proportional-hazards regression model was used to analyze the association between insufficient physical activity and cognitive impairment.Results:A total of 1904 subjects were included from the CHARLS national baseline survey in 2011,among whom 546(28.7％)had insufficient physical activity and 1358(71.3％)had sufficient physical activity.The subjects were followed up for 12001 person-years,with a mean follow-up time of(6.3±2.8)years,and during this period of time,324 subjects developed cognitive impairment,with a total incidence density of 2.70/100 person-years.The incidence density of cognitive impairment was 2.38/100 person-years in the subjects with sufficient physical activity and 3.56/100 person-years in those with insufficient physical activ-ity(P＜0.001).The multivariate Cox proportional-hazards regres-sion analysis showed that the risk of cognitive impairment in the subjects with insufficient physical activity was increased by 33％compared with that in the subjects with sufficient physical activity(hazard ratio=1.33,95％confidence interval:1.05-1.69).Conclusion:Insufficient physical activity increases the risk of cognitive im-pairment among middle-aged and elderly adults in rural areas of China,and it is recommended that middle-aged and elderly people take sufficient physical activity to effectively reduce or delay the development and progression of cognitive impairment.
rural areamiddle-aged and elderly adultsphysical activitycognitive function
万方数据
维普
