Research advances in the role of miRNA in pyroptosis during sepsis
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection and is an important cause of death in the intensive care unit.In recent years,numerous studies have shown that pyroptosis is closely associated with the develop-ment and progression of sepsis,and miRNA perform a variety of important cellular functions,including regulation of cell cycle,apoptosis,and differentiation.Recent studies have shown that miRNA play an important role in regulating pyroptosis,a programmed cell death associated with inflammatory response that plays a key role in many diseases,and miRNA are involved in the regulation of sepsis by acting directly or indirectly on the proteins of pyroptosis-related signaling pathway.This article summarizes the regulatory effect and role of miRNA in pyroptosis during sepsis,so as to provide new research directions and ideas for the research on pyroptosis during sepsis.
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