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功能性近红外光谱在抑郁症诊断及治疗监测中的临床应用

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抑郁症发病率快速上升,具有高致残率、高死亡率及高漏诊率等特点,目前抑郁症的诊断主要依靠临床症状和各种评定量表,缺乏客观的生物学指标.功能性近红外光谱是一种新兴无创的脑功能成像技术,2009年作为辅助诊断的生物学指标获得批准用于精神疾病的鉴别,尤其是在抑郁症中其临床应用和研究快速增加.本文将从功能性近红外光谱在诊断抑郁症、判断疾病程度、监测治疗反应及在青少年抑郁症中的应用方面进行全面的综述,为临床研究和运用提供指导.
Clinical application of functional near-infrared spectroscopy in the diagnosis and treatment monitoring of major depressive disorder
The incidence rate of major depressive disorder(MDD)is rising rapidly,with the characteristics of high disability rate,high mortality rate,and high missed diagnosis rate.At present,the diagnosis of MDD mainly relies on clinical symptoms and various rating scales,and there is still a lack of objective biological indicators.Functional near-infrared spectroscopy(fNIRS)is an emerging nonin-vasive brain functional imaging technique,and in 2009,it was approved for the identification of mental illnesses as a biological indica-tor for auxiliary diagnosis,especially in MDD,showing rapid increases in clinical application and studies.This article comprehensively reviews the application of fNIRS in diagnosing MDD,assessing disease severity,and monitoring treatment response,as well as its appli-cation in adolescent depression,so as to provide guidance for clinical research and application.

functional near-infrared spectroscopymajor depressive disorderdiagnosismonitoring

李夏颖、洪素、况利

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重庆医科大学附属第一医院精神科,重庆 400016

功能性近红外光谱 抑郁症 诊断 监测

国家自然科学基金资助项目

81971286

2024

重庆医科大学学报
重庆医科大学

重庆医科大学学报

CSTPCD北大核心
影响因子:0.724
ISSN:0253-3626
年,卷(期):2024.49(8)
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