Association between thyroid dysfunction and venous thrombosis:a two-sample bidirectional Mendelian randomization study
Objective:To investigate the causal relationship between thyroid dysfunction and venous thrombosis,and to provide genetic evidence for the association between thyroid dysfunction and the risk of venous thrombosis.Methods:The data of genome-wide associa-tion studies were used for analysis.In this study,thyroid stimulating hormone,free thyroxine,hyperthyroidism,and hypothyroidism were selected as exposure factors,and venous thromboembolism(VTE)was selected as the outcome variable,including deep vein thrombosis(DVT)and pulmonary embolism(PE).The inverse-variance weighted(IVW)method was used for assessing the causal rela-tionship between exposure factors and outcome variables,assisted by the MR-Egger,weighted median,and simple mode methods,and the Cochrane's Q test was used for sensitivity analysis.Results:The IVW analysis showed that hyperthyroidism had a positive causal relationship with VTE(odds ratio[OR]=1.074,95％CI=1.016～1.135,P=0.011),PE(OR=1.054,95％C I=1.012～1.098,P=0.011),and DVT(OR=1.068,95％CI=1.014～1.126,P=0.013).Conclusion:Based on genetic data,this study shows that there is a causal rela-tionship between thyroid dysfunction and VTE,and hyperthyroidism may increase the risk of VTE.
thyroid dysfunctionvenous thromboembolismMendelian Randomizationgenome-wide association studies
万方数据
维普
