Advances in the association between endoplasmic reticulum stress and human diseases
Endoplasmic reticulum is an important organelle of eukaryotic cells and is responsible for the synthesis,processing,and transportation of most proteins.In order to maintain the normal physiological function,endoplasmic reticulum is extremely sensitive to various predisposing factors and is restored to homeostasis by activating endoplasmic reticulum stress(ERS)to alleviate endoplasmic reticulum pressure,but persistent or severe ERS can promote cell apoptosis.Current studies have shown that ERS-mediated cell apop-tosis is closely associated with the development of diseases.This article reviews the research advances in the association between ERS and diseases,in order to provide new ideas for exploring the mechanism and targeted intervention of ERS in diseases.
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