Research progress on the neuroprotective effect of hypothalamic orexin in Parkinson's disease
Orexin is an important neuropeptide secreted by the hypothalamus and participates in a variety of brain activities.Parkinson's disease is a common neurodegenerative disease,and its occurrence is related to the progressive loss of dopamine neurons in the substantia nigra pars compacta and the formation of Lewy bodies in the hypothalamus.Previous studies found that the orexin system regulates dopamine function by directly acting on the orexin receptor in the ventral tegmental area where a large number of dopaminergic neurons are located.Additionally,dopamine participates in the regulation of the electrophysiological activity of orexin neurons.This paper discusses the neuroprotective effect of hypothalamic orexin system in Parkinson's disease,and briefly summarizes the effects and mechanisms of orexin on motor and non-motor symptoms of Parkinson's disease.
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