Chronic visceral pain(CVP)is one of the common symptoms of many diseases triggered by underlying diseases in the vis-ceral organs of the human body.Its causes include vascular mechanisms,mechanical factors,persistent inflammation,and unexplained functional mechanisms.Although the pathogenesis is unclear,more and more research has begun to shift from the neuronal aspect to glial cells in recent years.Spinal glial cells,particularly astrocytes and microglial cells,play an essential role in CVP.Based on this,this study elaborated on the mechanisms of action of astrocytes and microglial cells in CVP,including the release of cytokines,chemo-kines,and neuroactive substances and the alterations in intracellular signaling pathways.Because CVP is widespread in various dis-eases,drug treatments targeting astrocytes and microglial cells present broad application prospect.
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