Objective:To assess the efficacy and safety of a novel domestic single-port robotic surgical system for lobectomy through an animal experiment,and to lay the groundwork for its clinical application.Methods:An experimental Large White pig(male,40 kg)was selected to undergo left lower lobectomy and systematic lymph node dissection under the assistance of the SHURUI® single-port surgical robot.Its feasibility,safety,and efficacy during the perioperative period were evaluated.Results:Left lower lobectomy and systematic lymph node dissection were performed successfully with the single-port robotic surgical system with snake-like arms.The total operative time was 115 min,the docking time was 5 min,the operative time inside the chest cavity was 100 min,the time for lobec-tomy was 85 min,and the time for lymph node dissection was 15 min.The blood loss was about 20 mL.During operation,there was no damage to the lung,pericardium,vessels,or nerves;no conversion to open surgery;no interference or clash between instruments or instance of instruments moving away from the field of vision;no injuries of the vessels,lung,or chest wall caused by blind operation;and no system failure.The pig showed stable vital signs during and after the operation,and recovered well without relevant complications after the surgery.Conclusion:The SHURUI® single-port robotic surgical system is safe and feasible for performing lobectomy in pigs.