Objective This study intends to explore the effect of Treponema pallidum(TP)on HIV RNA and T cell counts in HIV primed patients,and the factors influencing baseline CD4+T below the lowest normal range in HIV primed patients.To provide a reference for determining the appropriate ART and syphilis treatment regimen for TP co-infected HIV patients in clinical diagnosis.Methods The present study included 106 cases of primary HIV infected patients admitted to our compassionate outpatient clinic,including 51 cases of TP co-infected with HIV(co-infected group)and 56 cases of HIV infected alone(simple infected group),with accurate recording of variables such as blood counts,biochemistry,T cell values,HIV RNA,and so on;The inclusion and exclusion criteria were established according to the 2022 Chinese Syphilis Guidelines and the 2021 Chinese AIDS Guidelines,and the effects of TP on baseline HIV RNA levels,T lymphocytes,and quantitative biochemical indexes in patients with primary HIV treatment,and the effect of CD4+T below the minimum normal range in patients with primary HIV treatment were analysed using chi-square test,Mann-Whitney test,and binary logistic regression.range of normal values.Results The differences in T-lymphocyte counts(CD4+,CD3+,and CD8+markers),CD4+/CD8+,and HIV RNA levels were not statistically significant in the co-infected group compared to the HIV primary patients in the infected-only group(P＞0.05).Leukocyte count and marital status(divorced or separated)as independent protective factors promoted baseline CD4+T lymphocyte values above the lowest normal range in HIV primaries with no risk factors.Conclusion Comorbid syphilis does not affect HIV RNA and T lymphocyte values in HIV primaries,but leukocyte count and marital status(divorced or separated)are Independent influencing factors that affect CD4+T-lymphocyte values.
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