Objective To investigate the difference of gastrointestinal symptoms in HIV/AIDS patients with different immune responses after combined antiretroviral therapy and analyze its influencing factors,so as to provide reference for immune reestablishment and disease control in HIV/AIDS patients after antiviral therapy. Methods The general and clinical data of 229 HIV/AIDS patients admitted and treated in the ward and outpatient department of Fifth Medical Center of PLA General Hospital from January 2021 to January 2024 were retrospectively analyzed by means of medical records and questionnaires. After 2 years or more of combined antiretroviral therapy,all patients were divided into groups according to their immune response status,and the differences in gastrointestinal symptoms were compared and the influencing factors were analyzed. Results Among the 229 patients,68 cases (29.69％) had digestive tract symptoms,among which the proportions of immune response patients,incomplete immune response patients and immune non-response patients were 31.19％,20.51％ and 32.10％,respectively. The most common symptom in the 3 groups was abdominal pain and diarrhea. The proportion was 19.27％,7.69％ and 17.28％,respectively. Logistic multivariate analysis found that gender being male,infection route being homosexual transmission. Conclusions Gastrointestinal symptoms are still common in HIV/AIDS patients after combined antiretroviral therapy,and the proportion of abdominal pain and diarrhea is the highest. The existence of such symptoms may be related to the gender of patients,infection route and CD4/CD8 ratio. Therefore,after antiviral treatment,patients with HIV/AIDS should continue to pay attention to their gastrointestinal symptoms and timely treatment,and regularly monitor their CD4+T cell and CD4/CD8 ratio levels,which is of important clinical significance for controlling digestive tract lesions and other HIV/AIDS-related complications and delaying the development of patients'disease.
维普
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