Objective The aim of this study was to investigate the efficacy and possible factors influencing the efficacy of national first-line free antiretroviral therapy (ART) for HIV/AIDS patients in Zhaojue County,Liangshan Prefecture,Sichuan Province,in order to provide a scientific basis for scientific and efficient work in the prevention and treatment of HIV/AIDS in Liangshan Prefecture. Methods In this study,a retrospective analysis was used to test the viral load of 1651 people living with HIV/AIDS (PLWH) who received at least 48 weeks of first-line ART by December 31,2020 in Liangshan Prefecture,and univariate and multivariate logistic regression analyses were performed using SPSS 26.0 software to identify the various factors affecting antiretroviral treatment failure (HIV RNA≥50 copies/mL). Results A total of 1651 PLWH were enrolled,53.1％ were male,median age was 35.00 (31.00,40.00) years,and virologic failure rate was 24.3％. Multifactorial logistic analysis showed that literacy (OR=0.11,95％ CI:0.01-1.00,P=0.047),and duration of treatment initiation (OR=1.002,95％ CI:1.001-1.003,P=0.003),were significant factors influencing antiviral outcomes. Adherence was identified as the most critical factor,with poorer adherence being associated with poorer antiviral treatment outcomes,with adherence grade 2 being 85.95 times more likely to fail antiviral treatment than grade 1 (95％ CI:4.27-1723.88,P=0.004). Conclusion Adherence is a major factor in antiretroviral treatment failure among PLWH in Liangshan State,and viral suppression failure should be reduced by improving patients'adherence to medication and starting antiretroviral therapy as early as possible.
维普
万方数据