Relationship between the expression levels of serum TPO and PGE2 with the severity and prognosis of patients with liver cirrhosis upper gastrointestinal bleeding
Objective To explore the relationship between serum thrombopoietin(TPO)and prostaglandin E2(PGE2)levels with the severity and prognosis of upper gastrointestinal bleeding(UGB)in patients with liver cirrhosis.Methods Selecting 103 patients with liver cirrhosis and UGB admitted to the Gastroenterology Department of Beidahuang Group General Hospital from April 2020 to April 2023 as the research subjects.Serum levels of TPO and PGE2 were measured using enzyme-linked immunosorbent assay(ELISA).The factors affecting the prognosis of UGB in liver cirrhosis were analyzed using logistic regression.The predictive value of serum TPO and PGE2 for the prognosis of UGB patients with liver cirrhosis was analyzed by plotting receiver operating characteristic(ROC)curves.Results The levels of serum TPO and PGE2 in UGB patients with mild,moderate,and severe cirrhosis were obviously reduced in sequence(P＜0.05).Compared with the survival group,the levels of serum TPO and PGE2 in the death group were obviously reduced(P＜0.05).There was a significant difference in the Child-Pugh grading of liver function between the death group and the survival group(P＜0.05).The high levels of TPO and PGE2 were protective factors affecting the prognosis of UGB patients with cirrhosis(P＜0.05),while the Child-Pugh grade C of liver function was identified as a risk factor affecting the prognosis of these patients(P＜0.05).The area under the curve(AUC)for the combined prediction of serum TPO and PGE2 levels for the prognosis of UGB patients with liver cirrhosis was the highest,which was better than the individual prediction of serum TPO and PGE2(P＜0.05).Conclusion The levels of serum TPO and PGE2 in patients with liver cirrhosis UGB are reduced,and the combination of these two markers can better predict the prognosis of liver cirrhosis UGB patients,demonstrating high predictive value.
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