Nocardia is an opportunistic pathogen found in soil,water and air.Nocardiosis is a zoonotic disease caused by Nocardia,with respiratory track as the main transmission route,and can also enter the human body through skin wounds,causing infection of the lungs、brain、skin and soft tissue,and rarely causing empyema.There are relatively few reports of Nocardiosis detected through metagenomic next-generation sequencing in peripheral blood.This paper reports a case of pulmonary infection,empyema and bacteremia caused by Nocardia farcinica,diagnosed by mNGS,aimed at to deepened the cognition of medical staff about the nocardiosis,early diagnosis and treatment can significantly improve the prognosis of patients.