首页|创伤失血性休克继发肝损伤机制的研究进展

创伤失血性休克继发肝损伤机制的研究进展

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近年来,随着地震灾难、道路交通事故、高空坠落等频发,创伤失血性休克临床发生率较高.创伤失血性休克导致各种脏器继发性损伤,肝损伤是其最常见的损伤.继发性肝损伤机制涉及内质网应激、肝脏纤维化、线粒体损伤、氧化应激和炎症反应等.本文就创伤失血性休克后继发性肝损伤病理生理特点结合机制研究的相关文献进行回顾并作综述,为进一步的研究提供理论指导.
Mechanism of liver injuries secondary to hemorrhagic shock after trauma
In recent years,with the frequent occurrence of conflicts,disasters,road traffic accidents,and falls from height,the incidence of hemorrhagic shock after trauma is common in clinical practice,with a risen number of patients.Hemorrhagic shock after trauma can lead to secondary injuries of various organs,among which liver injury is the most common type.The mechanisms of liver injuries secondary to trauma-related hemorrhagic shock involve endoplasmic reticulum stress,liver fibrosis,mitochondrial damage,oxidative stress,and inflammatory response,which are reviewed here based on related literature so as to provide theoritical basis for further research.

TraumaHemorrhagic shockLiver injuries

梁飞行、李佳佳、杨欣悦、屈金权、刘江伟

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新疆军区总医院新疆特殊环境医学重点实验室,乌鲁木齐 830000

石河子大学医学院,新疆 石河子 832000

创伤 失血性休克 肝损伤

新疆维吾尔自治区重点实验室开放课题

2020D04029

2024

创伤外科杂志
第三军医大学,大坪医院,野战外科研究所

创伤外科杂志

CSTPCD
影响因子:1.017
ISSN:1009-4237
年,卷(期):2024.26(7)