摘要
近年来,随着地震灾难、道路交通事故、高空坠落等频发,创伤失血性休克临床发生率较高.创伤失血性休克导致各种脏器继发性损伤,肝损伤是其最常见的损伤.继发性肝损伤机制涉及内质网应激、肝脏纤维化、线粒体损伤、氧化应激和炎症反应等.本文就创伤失血性休克后继发性肝损伤病理生理特点结合机制研究的相关文献进行回顾并作综述,为进一步的研究提供理论指导.
Abstract
In recent years,with the frequent occurrence of conflicts,disasters,road traffic accidents,and falls from height,the incidence of hemorrhagic shock after trauma is common in clinical practice,with a risen number of patients.Hemorrhagic shock after trauma can lead to secondary injuries of various organs,among which liver injury is the most common type.The mechanisms of liver injuries secondary to trauma-related hemorrhagic shock involve endoplasmic reticulum stress,liver fibrosis,mitochondrial damage,oxidative stress,and inflammatory response,which are reviewed here based on related literature so as to provide theoritical basis for further research.
基金项目
新疆维吾尔自治区重点实验室开放课题(2020D04029)
NETL
NSTL
万方数据