Relationship between apolipoprotein E gene polymorphism and cognitive dysfunction after traumatic brain injuries
Objective:To explore the relationship between apolipoprotein E(APOE)gene polymorphism and cognitive dysfunction(CD)after traumatic brain injuries(TBI).Methods Fifty-seven TBI patients with CD treated in the Department of Neurosurgery of Banan Hospital Affiliated to Chongqing Medical University from Jan.2018 to Feb.2023 were selected as the CD group;another 51 TBI patients admitted at the same time without CD were selected as the control group.The data of gender,age,GCS,injury severity,and combination of brain contu-sion/subarachnoid hemorrhage/subdural hematoma were recorded.Anticoagulant venous blood of 2-4 mL was sam-pled for all patients,and the DNA was extracted by multiple fluorescence PCR.An APOE gene detection kit was used to test the APOE alleles(ε2,ε3 and e4).Genotypic differences and the abovementioned parameters were compared between the two groups.Logistic regression analysis was used to screen risk factors of CD after TBI.Re-sults Gender,age,GCS,injury severity,and combination of brain contusion/subarachnoid hemorrhage/subdural he-matoma showed no significant differences between the two groups,except for the APOE alleles(P＜0.05),which re-vealed a significantly lower percent of ε3 gene carriers and a significantly higher percent of ε4 gene carriers in the CD group(both P＜0.05).Univariate logistic regression analysis of all the parameters showed that only the ε4 car-rier was a risk factor for CD after TBI(P=0.005,OR=0.317,95％CI=0.142-0.711);multifactorial logistic re-gression analysis of GCS,gender,injury severity,ε3 carrier and ε4 carrier showed the same result of the singer risk factor of ε4 carrier(P=0.039,OR=0.379,95％CI=0.150-0.954).Conclusion APOEe4 gene is associated with CD after TBI.
Brain injuriesApolipoprotein EApolipoprotein E genesCognitive dysfunction
万方数据
维普
