Detection and predictive value of mycoplasma pneumoniae deoxyribonucleic acid load and D-dimer、lactate dehydrogenase in alveolar lavage fluid of children with mycoplasma pneumoniae pneumonia
Objective To assess the predictive value of mycoplasma DNA(MP-DNA)load,D-dimer(D-D)level and lactate dehydrogenase(LDH)level in alveolar lavage fluid of children with mycoplasma pneumoniae pneumonia(MPP)on the severity of the disease.Methods One hundred and eighty children with MPP diagnosed in the Department of Infection of Anhui Children's Hospital from March to December 2023 were collected and divided into a severe group(76 cases)and a mild group(104 cases)according to their conditions.We compared the levels of MP-DNA load,D-D and LDH in alveolar lavage fluid between the two groups,analyzed the correlation between MP-DNA load and D-D and LDH,and evaluated the predictive value of the three indexes for severe MPP by ROC curve.Results MP-DNA load and D-D levels were significantly higher in the severe MPP group than in the mild group(P＜0.05).The difference in LDH levels was not statistically significant(P＞0.05).MP-DNA load was positively correlated with both D-D(r=0.496,P＜0.001)and LDH(r=0.325,P=0.004)levels,and the correlation with D-D was stronger.ROC curve analysis showed that the area under the curve(AUC)of MP-DNA load in predicting severe MPP was 0.740,which was significantly higher than that of D-D(AUC=0.614)and LDH(AUC=0.554).Conclusion MP-DNA load and D-D levels were significantly elevated in children with severe MPP and had significant predictive value,with MP-DNA load having a higher diagnostic efficacy.
万方数据
维普
