Effects of nicergoline combined with hyperbaric oxygen on neurological function and serum factors in acute ischemic stroke
Objective To investigate the effects of nicergoline combined with hyperbaric oxygen on neurological function and serum factors in acute ischemic stroke(AIS).Methods A total of 94 AIS patients admitted to Anqing 116th Hospital from October 2023 to February 2024 were selected as objects,including 47 males and 47 females,aged(62.01±7.15)years old,ranging from 52 to 70 years old;and they were randomly divided into hyperbaric oxygen group(n=46)and Niergoline group(n=48)by random number table method.Hyperbaric oxygen group was treated with hyperbaric oxygen combined with conventional treatment,and Niergoline group was treated with nicergoline on the basis of hyperbaric oxygen group.After 14 days of treatment,the therapeutic effect,nerve injury[National Institutes of Health Stroke Scale(NIHSS)score],self-care ability(Barthel index score),vascular endothelial growth factor(VEGF)level,neuron-specific enolase(NSE)level,inflammatory factor[hypersensitive C-reactive protein(hs-CRP)],interleukin-6(IL-6),lipoprotein-associated phospholipase A2(Lp-PLA2),tumor necrosis factor α(TNF-α)]and the incidence of adverse reactions were compared between the two groups were compared.Results The treatment effective rate of niergoline group was higher than that of hyperbaric oxygen group,and the difference was statistically significant(P＜0.05).After 14 days of treatment,the Barthel index score of the Niergoline group was higher than that of the hyperbaric oxygen group,and the NIHSS score and levels of VEGF,NSE,hs-CRP,Lp-PLA2,IL-6 and TNF-α were lower than those of the hyperbaric oxygen group,with statistical significance(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The effective rate of niergoline combined with hyperbaric oxygen in AIS treatment is high,which can promote the recovery of patients'neurological function,improve patients'self-care ability,and has high safety.
Acute ischemic strokeNicergolineHyperbaric oxygenSerum factorNeurological function
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