Predictive value of brain-type fatty acid binding protein and transferrin in children with sepsis associated encephalopathy
Objective To explore the predictive value of brain-type fatty acid binding protein(B-FABP)and transferrin(TRF)for sepsis-associated encephalopathy(SAE)in pediatric patients.Methods A total of 60 children with sepsis were selected from Xuzhou Children's Hospital from September 2021 to August 2023,including 41 males and 19 females,median aged 11.60 months,ranging from 1 to 72 months.Among them,30 children with consciou disturbance were in the SAE group,and 30 children without consciou disturbance were in the non-SAE group.Glasgow Coma Scale score(GCS),Pediatric critical illness score(PCIS)and serum samples were collected at 24,48 and 72 h upon admission.The expressions of B-FABP and TRF in serum were detected.The data and the levels of GCS,PCIS,B-FABP and TRF were compared between the two groups at admission.Receiver operating characteristic curve(ROC)evaluated the sensitivity,specificity and optimal threshold of B-FABP and TRF to predict SAE.The correlation between B-FABP,TRF,GCS and PCIS was analyzed.Results The expression of B-FABP in SAE group was higher than that in non-SAE group at different time points,and the expression of TRF was lower than that in non-SAE group,with statistical significance(P＜0.05).The area under the curve(AUC)of B-FABP at 24 hours for predicting SAE was 0.884,with a sensitivity of 93.33％and specificity of 76.67％.The AUC of TRF at 48 hours for predicting SAE was 0.877,with a sensitivity of 93.33％and specificity of 76.67％(P＜0.05).In the SAE group,B-FABP was negatively correlated with GCS score and PCIS,while TRF was positively correlated with GCS score and PCIS(P＜0.05).Conclusion Serum B-FABP and TRF may serve as diagnostic and prognostic biomarkers for pediatric SAE.
万方数据
维普
