A general palladium-catalyzed carbonylative synthesis ofα-CF3-substituted ketones and carboxylic acid derivatives
α-CF3-substituted carboxylic acid derivatives have drawn wide attention owing to their importance for both pharmaceutical and synthetic communities.However,methodologies for their construction are still very limited.Herein,we developed a general palladium-catalyzed carbonylative procedure for the synthesis of α-CF3-substituted ketones and carboxylic acid derivatives.With amines,phenols,alcohols,arylboronic acids,and even less-nucleophilic sulfonamides and amides as the reaction partners,the corresponding amides,esters,ketones and imides were obtained in good yields with excellent functional group tolerance.Furthermore,this protocol has also been applied to the late-stage modification of 25 densely functionalized pharmaceutical agents and natural products.
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