摘要
肌少症是一种与肌肉量减少、肌力下降、躯体功能减退相关的综合征.由于肿瘤代谢、系统性炎症反应、疾病进展和治疗副作用导致身体活动降低等多重因素,肺癌病人肌少症发生风险高于一般人群,且与临床预后密切相关,是死亡率的独立预测因子,并严重影响生活质量和心理情绪.本文系统综述了肺癌病人合并肌少症的影响因素、临床预后及对生活质量和心理情绪的负面影响和干预手段.鉴于合并肌少症对肺癌病人的重要影响,亟待探索多学科联合干预模式以改善其生存状态和生活质量.
Abstract
Sarcopenia is a syndrome associated with decreased muscle mass,decreased muscle strength,and reduced physical performance. Due to multiple factors such as tumor metabolism,systemic inflammatory response,disease progression,and reduced physical activity associated with treatment itself,the risk of sarcopenia in patients with lung cancer is higher than that of the general population. Sarcopenia is closely related to the clinical outcomes,including increased risk for mortality,and significantly impacts patients' long-term quality of life and mental health. This study systematic reviewed the risk factors for sarcopenia in patients with lung cancer,its negative effects on clinical outcomes,long-term quality of life and mental health,and the interventions for sarcopenia. Given the significant impact of sarcopenia on patients with lung cancer,it is urgent to explore a multidisciplinary intervention model to improve their survival and quality of life.
基金项目
国家自然科学基金(71874111)
国家自然科学基金(72004133)
上海市"科技创新行动计划"启明星计划(21QA1405300)
维普
万方数据