The lipid-reducing effects of Fuzhuan tea by inhibiting lipid synthesis have been reported in a number of studies,there are few studies on its regulation of lipid catabolism.In this study,we used Caenorhabditis elegans as model organisms,and analyzed the function and regulatory mechanism of Fuzhuan brick tea extract(FBTE)on lipid decomposition in C.elegans via by lipid staining,mutants,RNA interference and qPCR.We found that FBTE improved the fatty acid β-oxidation and the tricarboxylic acid cycle,and promoted the lipid catabolism by upregulating the expression nhr-49 and aco-1 in C.elegans,thereby reduced the fat storage.
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