Advances in Omics Research for Risk Assessment of Non-animal Alterna-tives to Organic Chemicals
Exposure assessment serves as a pivotal component in the risk evaluation of organic chemicals.Precise evaluation of the potential hazards posed by these chemicals to animals or humans is essential for effectively mitigating their associated risks.Traditional approaches to chemical risk assessment have traditionally relied on ani-mal studies.However,in vitro cytotoxicity experiments present distinct advantages,such as economic efficiency,rapid execution,ease of quantification,and reproducibility,when compared to intricate in vivo experiments.Quanti-tative automated high-throughput assays,particularly those employing human cells or cell lines,prove advantageous in delineating the toxic effects of chemical substances and addressing the regulatory requirements for controlling organic chemicals.As life sciences transition into the post-genomics era,research perspectives have been broadened.Leveraging omics tools like genomics,transcriptomics,proteomics,and metabolomics enables the provision of multi-dimensional insights for chemical exposure risk assessment.These insights encompass spatial and temporal distributions of gene expression,properties of protein structure and function,post-translational modifications of proteins,and dynamic changes in metabolites.This review systematically examines and outlines recent advancements in organic chemical risk assessment at both domestic and international levels.The review underscores the research strategy of omics and explores its application in organic chemical risk assessment,providing a comprehensive perspective.It is suggested that the collaborative application of omics methodologies will facilitate a more systematic and comprehensive exploration of the toxicity mechanisms of chemicals.Furthermore,this review puts forth technical guidelines and references to support the risk assessment of exposure to non-animal substitute organic chemicals in China.
organic chemical substancesin vitro risk assessmenttoxicity testomics techniques
万方数据
维普
