Photo-toxicity Effects and Mechanisms of Ultraviolet on Human Skin
Ultraviolet(UV)radiation is a form of non-ionizing radiation that is emitted by the sun and artificial light.The increasing outdoor UV radiation induced by reduction of the protective ozone layer,as well as the wide-spread application of UV in medical and production,making UV one of the most important physical factors in the environment.Human skin is the target organ of UV and UV radiation can cause a series of skin problems such as erythema,tanning,photoaging,inflammation and pigmentation.In polar and Qinghai-Tibet Plateau regions,skin damages caused by high dose of UV radiation are polar specific and highly prevalent diseases.In this article,we systematically reviewed the photo-toxicity effects and mechanisms of UV on human skin in oxidative stress,DNA damage,inflammation,immunosuppression and photoaging,which might be valuable for the biological damage and health risk assessment of UV radiation under specific environment,as well as the effectiveness and safety evalua-tion of anti-UV products.
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