Research on Relationship between Traditional/emerging Per/polyfluoroalkyl Substances in Chinese Serum and Human Body Function Indicators
In this study,we quantified twenty-five types of poly-and perfluoroalkyl substances(PFASs)in the serum of 53 residents from eastern coastal areas in China to investigate the associations between PFAS exposure and various biomarkers of liver and kidney function.These biomarkers included alkaline phosphatase(ALP),serum creatinine(SCR),and anti-RO52 antibody levels,among others.We detected 14 PFASs in the serum samples,with total concentrations(Σ14 PFASs)ranging from 5.48 to 297 ng·mL-1.Perfluorooctanoic acid(PFOA)and perfluorooctanesulfonic acid(PFOS)were the predominant contaminants,exhibiting median concentrations of 9.90 ng·mL-1 and 7.45 ng·mL-1,respectively.The only emerging polyfluorinated compound identified was chlorinated polyfluoroalkyl ether sulfonic acid(6:2 Cl-PFESA),with a median concentration of 0.84 ng·mL-1.Notably,perfluorobutanoic acid(PFBA)showed a significant positive correlation with ALP(r=0.588,P＜0.05),suggesting that increased PFBA levels may impair liver function.Conversely,PFOS was significantly negatively correlated with serum creatinine(r=-0.605,P＜0.05),indicating its detrimental effects on renal function.Additionally,a significant negative correlation was observed between perfluorononanoic acid(PFNA)and anti-RO52 antibody titers(r=-0.768,P＜0.01),highlighting PFNA as a potential risk factor for autoimmune diseases.
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