Application of New Approach Methodologies in Per-and Polyfluoroalkyl Substances(PFAS)
Before the 21st Century,plenty of laboratory animals were applied to assess the toxicity and potential health risks of compounds.However,with the growing production and application of huge number of new chemi-cals,these expensive and lengthy in vivo testing showed their limitations.To address this challenge,new approach methodologies have arisen in the 21 st Century.Many of these new strategies depend on in silico evaluation or in vitro toxicity pathway in human cells.The results from new strategies were expected to be more closely related to humans and more cost-effective to use.In this paper,we introduce these modern toxicity-testing strategies and their applications in the toxicological studies of per-and polyfluoroalkyl substances(PFAS).Finally,we summarize the deficiencies of new methods,and hope that improvements in these methods will lead to a promising application in the future.
new approach methodologiescomputational toxicologyrisk assessmenthigh-content screeningper-and polyfluoroalkyl substances
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