摘要
纳米颗粒物因其优异的性能在各个领域中都得到了广泛的应用.然而,这些纳米颗粒物的潜在健康风险,尤其是对胎儿发育的影响也受到越来越广泛的关注.干细胞的多向分化的特点使其逐渐成为了评估纳米颗粒物的安全性和发育毒性的有力工具.本综述深入分析了干细胞在金属和非金属纳米粒子的发育毒性研究中的现状.深入探讨了具有不同特性(如尺寸、形状、表面电荷等)的纳米颗粒物对干细胞的影响,以及由此产生的毒性效应的差异.最后强调了干细胞来源的类器官在纳米毒理学的研究中的潜力,为毒理学研究提供了更加准确的毒性评价模型.
Abstract
Nanoparticles,because of their unique physical and chemical properties,have been widely utilized in numerous fields.However,growing concerns are being raised regarding their potential health risks,particularly the impact on fetal development.Stem cells,with their capacity for self-renewal and differentiation,are emerging as valuable tools for assessing the safety and developmental toxicity of nanoparticles.This review examines the role of stem cells in evaluating the developmental toxicity of both metallic and non-metallic nanoparticles.It explores how nanoparticle characteristics,including size,shape,and surface charge,influence stem cell behavior and contribute to variations in toxicological outcomes.The review also underscores the promising role of stem cell-derived organoids in advancing nano toxicology,providing a more accurate and predictive model for toxicological studies.
基金项目
新疆维吾尔自治区杰出青年项目(2022D01E52)
国家自然科学基金青年基金(22206162)
新疆维吾尔自治区天山创新团队项目(2022D1400)
NETL
NSTL
万方数据