Application of Stem Cells in Investigation of Nanoparticles Toxicity Mechanisms
Nanoparticles,because of their unique physical and chemical properties,have been widely utilized in numerous fields.However,growing concerns are being raised regarding their potential health risks,particularly the impact on fetal development.Stem cells,with their capacity for self-renewal and differentiation,are emerging as valuable tools for assessing the safety and developmental toxicity of nanoparticles.This review examines the role of stem cells in evaluating the developmental toxicity of both metallic and non-metallic nanoparticles.It explores how nanoparticle characteristics,including size,shape,and surface charge,influence stem cell behavior and contribute to variations in toxicological outcomes.The review also underscores the promising role of stem cell-derived organoids in advancing nano toxicology,providing a more accurate and predictive model for toxicological studies.
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