Risk Assessment of Ingestion Exposure to Per-and Poly-fluoroalkyl Sub-stances among Elderly People in a Community in Shanghai
Per-and poly-fluoroalkyl substances(PFAS)are ubiquitous in the human body,yet the exposure characteristics among the elderly remain understudied.This study is to evaluate the health risks and dietary exposure characteristics of PFAS among the elderly in Shanghai.We conducted a cross-sectional study and collected a total of 68 valid questionnaires from individuals aged 60～79 in Shanghai.Combined with dietary PFAS concentration data from the 6th National Total Dietary Study of China,we employed a Monte Carlo model to perform a probability assessment of dietary exposure.Health risks were evaluated based on the weekly tolerable intake of four PFAS i.e.,perfluorooctanoic acid(PFOA),perfluorooctane sulfonic acid(PFOS),perfluorohexane sulfonic acid(PFHxS),and perfluorononanoic acid(PFNA)as adopted by the European Food Safety Agency.The results showed a dietary composition dominated by fruits(1 440.0 g·week-1),grains(1 341.0 g·week-1),and dairy products(835.0 g·week-1),accounting for 24.8％,23.1％,and 14.4％of the total diet,respectively.Total dietary exposure to the four PFAS was(1 024.7±140.3)pg·kg-1·d-1,with aquatic products contributing the most(53.5％).The dietary expo-sure doses of PFOA,PFOS,PFHxS and PFNA were(308.4±36.5),(519.2±104.2),(49.8±7.6),and(73.3±13.6)pg·kg-1·d-1 respectively,with eggs(48.9％),aquatic products(75.1％),grains(64.9％),and aquatic products(76.3％)being the primary sources respectively.Health risk(HR)for PFOA and PFOS were 0.36 and 0.32,respec-tively.The total health risk of four PFAS was 1.63,primarily from aquatic products(53.5％),followed by eggs(20.9％)and meat(15.5％).Gender-based analysis revealed consistent results with the exposure risk for females from aquatic products significantly higher than males(mean:67.3％＞43.8％,P＜0.001).In summary,dietary exposure to PFAS poses notable health risks among the elderly population in Shanghai.Aquatic products were the main source of total four PFAS and individual PFOS;eggs and meat had a prominent contribution for PFOA.This study clarifies the risk and source characteristics of PFAS exposure in the elderly population in Shanghai,providing basic data for further study into PFAS exposure sources,accumulation and migration patterns in population.
NETL
NSTL
万方数据
