Construction of a Physiologically Based Toxicokinetic(PBTK)Model of Tris(2-chloroethyl)Phosphate(TCEP)in Chinese Adults
With the global ban on brominated flame retardants,organophosphate esters(OPEs)have been exten-sively manufactured in China as a primary substitute.These compounds are widely used in various fields,including food plastic containers,interior decoration materials,and industrial manufacturing.Among them,tris(2-chloroethyl)phosphate(TCEP)has been classified as a reproductive toxin and a suspected human carcinogen by the relevant EU regulations,making it a controlled substance.To better understand and establish the link between dietary expo-sure to TCEP and human health,this study constructed a physiologically based toxicokinetic(PBTK)model using the Gastroplus software,based on the physiological parameters of Chinese adults and the physicochemical proper-ties of TCEP.This model described the absorption,metabolism,distribution,and excretion kinetics of TCEP in the human body.The constructed PBTK model predicted the steady-state concentrations of TCEP in human or mam-malian tissues and organs such as blood,brain,liver,and kidney following TCEP exposure.Accuracy,sensitivity,and correlation analyses were carried out,indicating that the model performance was acceptable for regulatory pur-poses.The model's validity was further supported by comparing TCEP plasma levels from mouse studies and serum levels from Chinese adults,as reported in the literature,affirming its utility for assessing health risks associated with dietary TCEP exposure.
tris(2-chloroethyl)phosphate(TCEP)physiologically based toxicokinetic model(PBTK model)dietary exposuremodel verification
万方数据
维普
