Acute Toxicity of Short-chain Perfluorinated Compounds PFBA and PFBS on Neocaridina denticulata:Mortality and Effects on Four Biomarkers
In recent years,short chain perfluorinated compounds(PFASs)have been widely used as substitutes for long-chain PFASs in industrial production and commercial products.Concerns have been raised about the environ-mental effects of perfluoroalkyl substances(PFASs)because of their toxicity,widespread distribution,and persis-tence.In this study,the acute toxicity of two short-chain perfluorochemicals,perfluorobutyric acid(PFBA)and per-fluorobutane sulfonic acid(PFBS),on black shell shrimp(Neocaridina denticulata)was evaluated using mortality and the activities of catalase(CAT),superoxide dismutase(SOD)and acetylcholinesterase(AChE),and malondial-dehyde(MDA)content as endpoints.The findings revealed that the 96 h-LC50 of Neocaridina denticulata exposure to PFBA and PFBS were 7.866 mg·L-1and 0.713 g·L-1,respectively.A concentration-dependent of CAT,SOD,AChE and MDA level was found in organisms exposed to PFBA and PFBS.The MDA content exhibited a signifi-cant increase with elevated exposure concentrations of PFBS.Conversely,the CAT,SOD,AChE enzyme activity showed an inverted"U"curve relationship of initially increasing and subsequently declining with rising exposure concentrations of PFBS and PFBA.The results demonstrate that PFBA and PFBS can interfere with enzyme activi-ties in black shell shrimp to varying degrees.Furthermore,they induce a series of oxidative damage in the medium and low concentrations,while high concentrations cause oxidative stress,ultimately leading to death.This study provides a scientific basis for investigating the toxic mechanisms of short chain perfluorinated compounds on aquatic organisms.
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