The objective of this study is to investigate the relationship between the acute toxic effects of sodium arsenite on male Kunming mice and the exposure routes through which they occur.The methodology employed involved the administration of varying concentrations of sodium arsenite solution via intragastric and tracheal instillation to Kunming mice.The acute toxic effects of these doses were then observed and recorded.The median lethal dose(LD50)was determined using the modified Karber method.The results demonstrated that following exposure to sodium arsenite,the animals in each dose group exhibited symptoms indicative of poisoning,including decreased activity,unresponsiveness,shortness of breath,drowsiness and fatigue.Additionally,mice in the high-dose group exhibited toxic phenomena,including convulsions,prior to death.The LD50 value of sodium arsenite in the gastric gavage exposure group was determined to be 63.09 mg·kg-1,with a 95％confidence interval of 49.00 to 81.96 mg·kg-1.The LD50 value of the tracheal instillation exposure group was 57.54 mg·kg-1,with a 95％confidence interval of 43.15 to 76.74 mg·kg-1.It can be concluded that the toxicity of intragastric administration of sodium arsenite is lower compared to intratracheal instillation.
维普
万方数据