Analysis of Clinical Application of Camrelizumab Combined with Lenvatinib in Primary Liver Cancer
Objective:To investigate the clinical efficacy of Camrelizumab combined with Lenvatinib in the treatment of primary liver cancer,and analyze its impact on tumor markers,liver function,and serum cytokine levels.Methods:A total of 95 patients with primary liver cancer were selected as the research subjects and randomly divided into a control group(lenvatinib)of 47 cases and an observation group(Camrelizumab combined with Lenvatinib)of 48 cases.The treatment was conducted for 3 consecutive cy-cles with 3 weeks as a cycle.The concentrations were compared before and after treatment between the two groups in terms of clini-cal efficacy and liver function[Alanine aminotransferase(ALT),total bilirubin(TBIL),albumin(ALB)],tumor markers[Al-pha-fetoprotein(AFP),carcinoembryonic antigen(CEA),glycan antigen 199(CA199)],serum cytokines[Vascular endothelial growth factor(VEGF),pigmentation box homologous protein 7(CBX7),epithelial calcium adhesin gene protein(CDH1)],and serum microRNA-21(miR-21)/sclerostin domain-containing protein 1(SOSTDC1)pathway-related factors(miR-21,SOSTDC1 mRNA).The occurrence of toxic side effects during the treatment was also compared between the two groups.Results:The objec-tive response rate(56.25%)and local control rate(89.58%)in the study group were higher than those in the control group(25.53%and 72.34%,respectively)(P<0.05);the levels of AFP,CEA,and CA199 in the study group after treatment were lower than those in the control group;the levels of serum VEGF,CBX7,CDH1,and miR-21 in the study group after treatment were lower than those in the control group,while the level of serum SOSTDC1 mRNA was higher than that in the control group(P<0.05);there was no significant difference in the incidence of toxic side effects between the two groups(P>0.05).Conclusion:The combination of camrelizumab and lenvatinib in the treatment of primary liver cancer can improve the objective response rate and local control rate,and has certain safety.It may play a role by regulating the miR-21/SOSTDC1 pathway.
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维普
