Therapeutic Effect of Different Arfificial Valve Replacements in the Treatment of Valvular Heart Disease
Objective:To investigate the efficacy of different valve replacements in the treatment of valvular heart disease(VHD)and its effect on serum B-type natriuretic peptide(BNP)and inflammatory cytokines.Methods:A total of 100 patients with VHD treated were selected.Patients were divided into two groups of the biological valve group(50 cases)and the mechanical valve group(50 cases)by random number generation method.The clinical efficacy,safety,serum BNP and inflammatory factors[tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-6(IL-6)]were compared between the two groups.Results:There was no significant difference in the comparison of the total effective rate between the two groups(P>0.05).After 12 months of treatment,the levels of serum BNP in the two groups were decreased when compared with those before treatment(P<0.05),and the levels in the biological valve group were lower than those in the mechanical valve group[(117.19±13.19)ng·L-1 vs(136.95±14.86)ng·L-1](P<0.05).Three days after the operation,the levels of TNF-α,CRP and IL-6 in the two groups were higher than those before treatment(P<0.05),but the levels in the biological valve group were lower than those in the me-chanical valve group(P<0.05).There was no significant difference in the comparison of the incidences of perivalvular leak,endo-carditis and thromboembolism between the two groups(P>0.05).However,the incidence of bleeding events in the mechanical valve group was higher than that in the biological valve group(16.00%vs 4.00%)(P<0.05).Conclusion:The effect of biological valve replacement in the treatment of VHD is similar to that of mechanical valve replacement,but the postoperative inflammatory stress response is lighter and the incidence of bleeding events is lower.
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NSTL
万方数据
维普
