The Predictive Value of Serum C-reactive Protein to Albumin Ratio,Urinary Matrix Metalloproteinase-7,and Microalbumin for Prosthetic Infection After Hip Replacement Surgery
Objective:To analyze the predictive value of serum C-reactive protein to albumin ratio(CRP/ALB),urinary matrix met-alloproteinase-7(MMP-7),and microalbumin(MA)for prosthetic infection after hip replacement surgery.Methods:A total of 187 pa-tients who underwent hip replacement surgery were included as the study subjects,and the infection status of the patients was followed up for 90 days.Among them,28 patients with postoperative prosthetic infection were set as the infection group,and 159 patients without in-fection were set as the control group.We performed univariate analysis on the data of two groups of patients,performed logistic multivari-ate analysis on statistically significant factors,analyzed the risk factors for prosthetic infection after hip replacement surgery,and analyzed the predictive value of CRP/ALB,MMP-7,and MA for prosthetic infection after hip replacement surgery.Results:The BMI level,inci-dence of surgical history in the affected area,surgical time,postoperative drainage volume on the first day,total postoperative drainage volume,length of hospital stay,incidence of hormone use history,hypoalbuminemia,anemia,white blood cell urine,C-reactive protein(CRP)level,CRP/ALB level,MMP-7 level,MA level,and history of immunosuppressive therapy in the infection group were all higher than those in the control group,and the difference was statistically significant(P<0.05).The results of logistic analysis results showed that CRP/ALB≥2.5 and MMP-7≥22 μg·g-1 and MA≥15 mg·L-1 were both risk factors for prosthetic infection after hip replacement sur-gery(P<0.05).CRP/ALB,MMP-7,and MA all had certain predictive value for prosthetic infections after hip replacement surgery,but the predictive value of CRP/ALB+MMP-7+MA was higher than other single item predictions.Conclusion:CRP/ALB≥2.5,MMP-7≥22 μg·g-1 and MA≥15 mg·L-1 are both risk factors for prosthetic infection after hip replacement surgery,and their combined use has better predictive value for prosthetic infection after hip replacement surgery.
hip replacement surgeryprostate infectionc-reactive protein to albumin ratiourinary matrix metalloproteinase-7microalbumin
NETL
NSTL
万方数据
维普
