Bidirectional Two-Sample Mendelian Randomization Study on the Causal Association between Rheumatoid Arthritis and Schizophrenia
Objective:To explore the causal association between rheumatoid arthritis(RA)and schizophrenia.Methods:Pub-licly available summary datasets from genome-wide association studies were utilized.Two-sample MR analyses were conducted using inverse variance-weighted(IVW),weighted median,MR-Egger regression,simple mode,and weighted mode methods to infer the association between rheumatoid arthritis and schizophrenia.Additionally,bidirectional MR analysis was performed to examine the direction of causal associations.Results:The summary data included 8 255 cases in the RA group and 409 001 in the control group,with 19 SNPs selected as instrumental variables.MR analysis results indicated a causal association with an increased risk of schizophrenia in individuals with RA(IVW:OR=1.091,95%CI:1.028～1.158,P=0.004).However,no causal association was found between schizophrenia and an increased risk of RA(IVW:OR=0.997,95%CI:0.943～1.055,P=0.926).Conclusion:A causal association with an increased risk of schizophrenia in individuals with RA,but there is no evidence to support a causal associ-ation between schizophrenia and an increased risk of RA.
rheumatoid arthritisschizophreniamendelian randomizationcausal association
万方数据
维普
