长治医学院学报2024，Vol.38Issue(6) ：424-429.

类风湿关节炎与精神分裂症因果关联的双向孟德尔随机化研究

Bidirectional Two-Sample Mendelian Randomization Study on the Causal Association between Rheumatoid Arthritis and Schizophrenia

沈玥 韩梦琦 洪程 郭鑫 袁慧
长治医学院学报2024，Vol.38Issue(6) ：424-429.
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  • 维普
  • 万方数据

类风湿关节炎与精神分裂症因果关联的双向孟德尔随机化研究

Bidirectional Two-Sample Mendelian Randomization Study on the Causal Association between Rheumatoid Arthritis and Schizophrenia

沈玥 1韩梦琦 1洪程 1郭鑫 1袁慧1
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作者信息

  • 1. 皖南医学院公共卫生学院(安徽 芜湖 241000)
  • 折叠

摘要

目的:探讨类风湿关节炎(RA)与精神分裂症的因果关联.方法:采用公开的全基因组关联研究汇总数据集,通过逆方差加权法(IVW)、加权中位数法、MR-Egger回归法、简单模式法(Simple mode)和加权模式法(Weighted mode)进行两样本的MR研究,以推断类风湿关节炎和精神分裂症之间的关联.进行双向因果关联的MR分析,检验因果关联的发展方向.采用Cochran's Q检验判断异质性,MR-Egger回归法评估多效性,留一法排除异常值.结果:RA汇总数据包含8 255 例病例组和 409 001 例对照组,筛选出19 个SNPs作为工具变量;精神分裂症汇总数据包含33 640 例病例组和43 456 例对照组;MR分析结果表明,RA与精神分裂症风险增加存在因果关联(IVW:OR=1.091,95%CI:1.028～1.158,P=0.004),精神分裂症与RA风险增加未发现因果关联(IVW:OR=0.997,95%CI:0.943～1.055,P=0.926).结论:RA与精神分裂症风险增加存在因果关联,但不支持精神分裂症与RA风险增加的因果关联.

Abstract

Objective:To explore the causal association between rheumatoid arthritis(RA)and schizophrenia.Methods:Pub-licly available summary datasets from genome-wide association studies were utilized.Two-sample MR analyses were conducted using inverse variance-weighted(IVW),weighted median,MR-Egger regression,simple mode,and weighted mode methods to infer the association between rheumatoid arthritis and schizophrenia.Additionally,bidirectional MR analysis was performed to examine the direction of causal associations.Results:The summary data included 8 255 cases in the RA group and 409 001 in the control group,with 19 SNPs selected as instrumental variables.MR analysis results indicated a causal association with an increased risk of schizophrenia in individuals with RA(IVW:OR=1.091,95%CI:1.028～1.158,P=0.004).However,no causal association was found between schizophrenia and an increased risk of RA(IVW:OR=0.997,95%CI:0.943～1.055,P=0.926).Conclusion:A causal association with an increased risk of schizophrenia in individuals with RA,but there is no evidence to support a causal associ-ation between schizophrenia and an increased risk of RA.

关键词

类风湿关节炎/精神分裂症/孟德尔随机化/因果关联

Key words

rheumatoid arthritis/schizophrenia/mendelian randomization/causal association

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出版年

2024
长治医学院学报
长治医学院

长治医学院学报

影响因子：0.609
ISSN：1006-0588
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