首页|血清炎症因子与特发性少弱精子症患者精子DNA碎片指数的相关性研究

血清炎症因子与特发性少弱精子症患者精子DNA碎片指数的相关性研究

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目的:探讨特发性少弱精子症患者血清炎症因子与精子DNA碎片指数的相关性.方法:选择120 例特发性少弱精子症患者为观察组,另选择同期进行常规精液分析且结果正常的 100 例男性为对照组.对2 组研究对象精子DNA碎片指数、血清炎症因子水平进行检测并对比,比较观察组患者不同年龄、禁欲时长、精子活力等特征下的精子碎片指数,采用线性回归分析特发性少弱精子症患者血清炎症因子水平及精子活力、浓度与精子DNA碎片指数的相关性,采用Pearson相关性检验分析血清炎症因子与特发性少弱精子症患者精子DNA碎片指数的相关性.结果:观察组患者血清白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)、精子DNA碎片指数均高于对照组;精子活力≤20%、精子浓度≤10×106 mL-1 的患者精子DNA碎片指数高于精子活力>20%、精子浓度>10×106 mL-1 的患者;线性回归结果显示,特发性少弱精子症患者血清炎症因子水平、精子活力、精子浓度均与精子DNA碎片指数存在相关性(P<0.05);Pearson分析结果显示,血清IL-10、TNF-α 与精子DNA 碎片指数均呈正相关(P<0.05).结论:血清IL-10、TNF-α与特发性少弱精子症患者精子DNA碎片指数均呈正相关,血清IL-10、TNF-α水平的上升会对精子DNA的完整性形成破坏,引发精子DNA碎片指数上升.
Correlation between Serum Inflammatory Factors and Sperm DNA Fragmentation Index in Patients with Idiopathic Oligonasthenospermia
Objective:To investigate the correlation between serum inflammatory factors and sperm DNA fragmentation index in patients with idiopathic oligonasthenospermia.Methods:A total of 120 patients with idiopathic oligoasthenospermia were selected as the observation group,and another 100 men with normal semen analysis were selected as the control group.The sperm DNA frag-mentation index and serum inflammatory factor levels of two groups were detected and compared.The sperm fragmentation index un-der different age,abstinence duration,sperm motility and other characteristics of the observation group were compared.Linear re-gression was used to analyze the correlation between serum inflammatory factor levels,sperm motility,concentration and sperm DNA fragmentation index of the patients with idiopathic oligonasoospermia.Pearson correlation test was used to analyze the correlation be-tween serum inflammatory factors and sperm DNA fragmentation index in patients with idiopathic oligonasoospermia.Results:Serum IL-10,TNF-α,and sperm DNA fragmentation index in the observation group were higher than those in the control group.The sperm DNA fragmentation index of patients with sperm motility≤20%and sperm concentration≤10×106 mL-1 were higher than that of patients with sperm motility>20%and sperm concentration>10×106 mL-1.Linear regression results showed that serum in-flammatory factors,sperm motility and sperm concentration were correlated with sperm DNA fragmentation index in idiopathic oligo-nasoospermia patients(P<0.05).The results of Pearson analysis showed that serum IL-10,TNF-α and sperm DNA fragmentation index were positively correlated(P<0.05).Conclusion:Serum IL-10 and TNF-α are positively correlated with sperm DNA frag-mentation index in patients with idiopathic oligonasthenospermia.The increase of serum IL-10 and TNF-α levels will damage the integrity of sperm DNA and lead to the increase of sperm DNA fragmentation index.

interleukin-10tumor necrosis factor-αidiopathic oligonasthenospermiasperm DNA fragmentation indexcorrelation

王楠、张宏威

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南阳市第一人民医院生殖医学科(河南 南阳 473000)

白细胞介素-10 肿瘤坏死因子-α 特发性少弱精子症 精子DNA碎片指数 相关性

2024

长治医学院学报
长治医学院

长治医学院学报

影响因子：0.609
ISSN：1006-0588
年,卷(期)：2024.38(6)