Clinical Observation of Huanglian Wendan Decoction in the Treatment of Senile Chronic Insomnia with Internal Disturbance of Phlegm-heat
Objective:To investigate the effect of Huanglian Wendan Decoction combined with conventional treatment on the clinical efficacy of elderly chronic insomia patients with phlegm-heat internal disturbance.Methods:92 elderly patients with chronic insomnia were divided into 2 groups by random number table method.The control group was treated with estazolam,and the obser-vation group was treated with esazolam combined with Huanglian Wendan Decoction.46 cases in each group and both groups were treated continously for 4 weeks.The clinical efficacy,the score of TCM syndromes before and after treatment,serum neurotransmit-ters[serum 5-hydroxytryptamine(5-HT),norepinephrine(NE)level]and sleep quality score[Pittsburgh sleep quality index(PSQI)score]of the two groups were compared,and adverse reactions occured during treatment.Results:The total effective rate of the observation group was 95.65%higher than that of the control group(80.43%)(P<0.05).After 4 weeks of treatment,the TCM syndrome score of 2 groups(restlessness,bitter mouth and phlegm,chest tightness and abdominal congestion)decreased,and the ob-servation group was lower than the control group(P<0.05).After 4 weeks of treatment,NE levels in 2 groups decreased,and observa-tion group was lower than the control group;5-HT levels increased,and the observation group was higher than the control group,which the differences were statistically significant(P<0.05).After 2 and 4 weeks of treatment,the PSQI score of observation group was lower than that of control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group(23.91%)and the control group(34.78%)(P>0.05).Conclusion:The combination of conventional western medicine with Huanglian Wendan Decoction can improve clinical symptoms and regulate neurotransmitter metabolism in elderly pa-tients with chronic insomnia caused by internal disturbance of phlegm-heat,which the efficacy is remarkable and the safety is good.
chronic insomniainternal disturbance of phlegm-heatHuanglian Wendan Decoctionestazolam
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维普
