结直肠肛门外科2024,Vol.30Issue(1) :1-7.DOI:10.19668/j.cnki.issn1674-0491.2024.01.001

肿瘤疫苗在结直肠癌治疗中的研究进展

Research advance of tumor vaccines in the treatment of colorectal cancer

刘欣 陈征 孟晓东 贾艳 高春芳
结直肠肛门外科2024,Vol.30Issue(1) :1-7.DOI:10.19668/j.cnki.issn1674-0491.2024.01.001

肿瘤疫苗在结直肠癌治疗中的研究进展

Research advance of tumor vaccines in the treatment of colorectal cancer

刘欣 1陈征 1孟晓东 2贾艳 3高春芳1
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作者信息

  • 1. 中国人民解放军联勤保障部队第九八九医院全军肛肠外科研究所 河南洛阳 471000
  • 2. 中国人民解放军联勤保障部队第九八九医院检验输血科 河南洛阳 471000
  • 3. 南京大学医学院附属苏州医院护理部 江苏苏州 215000
  • 折叠

摘要

结直肠癌是我国最常见的消化道恶性肿瘤之一,其持续上升的发病率和死亡率,给患者的生存和预后带来了巨大的压力,严重影响患者的生活质量.近年来,随着对肿瘤免疫逃逸机制研究的不断深入,出现了各种新型免疫疗法,一定程度上弥补了传统疗法治疗效果差和毒副作用大等缺点.肿瘤疫苗作为一种新兴的免疫疗法,能够刺激机体产生针对肿瘤抗原的特异性免疫应答,激活细胞免疫,清除肿瘤细胞,抑制肿瘤生长.本文就不同类别的结直肠癌疫苗及其在结直肠癌治疗中的临床应用效果进行综述.

Abstract

Colorectal cancer(CRC)is one of the most common malignant tumors of the digestive tract in China,with a continuously increasing incidence and mortality rate,posing significant pressure on patients'survival and prognosis and seriously affecting their quality of life.In recent years,with the continuous deepening of research on tumor immune eva-sion mechanisms,various novel immunotherapies have emerged,which have somewhat compensated for the shortcomings of traditional therapies,such as poor treatment effects and significant toxic and side effects.As an emerging immuno-therapy,tumor vaccines can stimulate the body to produce specific immune responses against tumor antigens,activate cel-lular immunity,eliminate tumor cells,and inhibit tumor growth.This article provides a comprehensive review of different types of CRC vaccines and their clinical application effects in the treatment of CRC.

关键词

结直肠癌/肿瘤疫苗/治疗/研究进展

Key words

colorectal cancer/tumor vaccine/treatment/research advance

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出版年

2024
结直肠肛门外科
广西医科大学

结直肠肛门外科

CSTPCD
影响因子:0.957
ISSN:1674-0491
参考文献量48
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