体表电极胫神经电刺激治疗62例直肠癌低位前切除综合征患者的临床疗效观察
Observation of clinical effect of transcutaneous tibial nerve stimulation in the treatment of 62 cases of low anterior resection syndrome after rectal cancer surgery
张建华 1曾译贤 2王晓锋3
作者信息
- 1. 太原市中心医院肛肠科 山西太原 102499
- 2. 广州中医药大学第一附属医院重庆医院肛肠科 重庆 400700
- 3. 中国中医科学院广安门医院肛肠科 北京 100053
- 折叠
摘要
目的 探讨体表电极胫神经电刺激(transcutaneous tibial nerve stimulation,TTNS)治疗直肠癌低位前切除综合征(low anterior resection syndrome,LARS)的临床疗效.方法 采取自身前后对照单样本试验,回顾性分析中国中医科学院广安门医院肛肠科于2020年1月至2023年7月期间应用TTNS治疗的65例符合研究纳入标准的LARS患者的临床资料,单次刺激30 min,每周治疗3次,连续治疗3个月,进行疗效观察及安全性评价.结果 共62例患者完成临床试验,与治疗前比较,治疗后患者的LARS评分、Wexner大便失禁评分均降低,纪念斯隆—凯特林癌症中心(the Memorial Sloan-Kettering Cancer Center Bowel Function Instrument,MSKCC)肠道功能问卷评分升高,差异有统计学意义(P＜0.05);欧洲癌症研究与治疗组织生命质量量表评分(European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30,EORTC QLQ-C30)问卷中的总体健康水平、社会功能维度评分升高,疲倦、疼痛、失眠、腹泻症状维度评分下降,差异有统计学意义(P＜0.05).所有受试者均未出现严重不良反应.结论 TTNS治疗可有效改善LARS患者的临床症状,改善患者肠道功能及生活质量,为LARS临床多模式治疗提供临床选择.
Abstract
Objectives To investigate the preliminary clinical effect of transcutaneous tibial nerve stimulation(TTNS)in the treatment of low anterior resection syndrome(LARS)after rectal cancer surgery,and to provide practical evidence for further exploring clinical treatment strategies for LARS.Methods A single-sample trial with self-comparison before and after treatment was conducted.We retrospectively analyzed the clinical data of 65 patients with LARS who met the inclusion criteria and received TTNS treatment in the department of anorectal surgery,Guang'anmen Hospital,China Na-tional Academy of Chinese Medical Sciences from January 2020 to July 2023.Each stimulation session lasted for 30 min-utes,with three treatments per week for a continuous period of 3 months.Clinical observations and safety evaluations were conducted.Results A total of 62 patients completed the clinical trial.Compared with before treatment,the LARS score and Wexner incontinence score were reduced,while the Memorial Sloan-Kettering Cancer Center(MSKCC)intestinal function questionnaire score was improved after treatment,with statistically significant differences(P＜0.05).Compared with before treatment,the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30(EORTC QLQ-C30)score showed an increase in overall health level and social function dimensions,and a de-crease in fatigue,pain,insomnia,and diarrhea symptom dimensions after treatment,with statistically significant differ-ences(P＜0.05).No serious adverse reactions were observed in any of the subjects.Conclusion TTNS treatment can ef-fectively improve the clinical symptoms,intestinal function,and quality of life of patients with LARS,providing a clinical option for multimodal treatment of LARS.
关键词
直肠癌/体表电极胫神经电刺激/低位前切除综合征/临床疗效Key words
rectal cancer/transcutaneous tibial nerve stimulation/low anterior resection syndrome/clinical effect引用本文复制引用
基金项目
中国中医科学院科技创新工程重大攻关项目(CI2021A02109)
出版年
2024
国家科技期刊平台
NSTL
万方数据