Objectives To observe the efficacy and safety of oral capsule fecal microbiota transplantation(FMT)in the treatment of refractory functional constipation.Methods A total of 36 patients with refractory functional constipation ad-mitted to the Department of Defecation Disorders,Shenyang Anorectal Hospital,were enrolled and treated with oral cap-sule FMT.The number of patients with bowel movements＞3 times/week and stool consistency of Bristol type 3 or 4 was recorded before treatment,1 month after treatment,and 6 months after treatment.The Constipation System Score(CSS)and the Patient Assessment of Constipation Quality of Life Score(PAC-Qol)were administered.Analyze the defeca-tion situation and clinical efficacy of patients.Results The number of patients with bowel movements＞3 times/week before FMT,1 month after FMT,and 6 months after FMT were 13(36.1％),23(63.9％),and 22(61.1％),respectively.The number of patients with Bristol type 3 or 4 stool consistency were 9(25％),24(66.7％),and 16(44.4％),respec-tively.The CSS and the PAC-Qol were significantly lower at 1 month and 6 months post-FMT compared to pre-FMT(P＜0.05).After 1 month of FMT,5 patients were cured,11 showed marked improvement,11 were effective,and 9 were inef-fective,with an overall effective rate of 75％.After 6 months of FMT,6 patients were cured,5 showed marked improve-ment,9 were effective,and 16 were ineffective,with an overall effective rate of 55.6％.There was no significant differ-ence in the overall effective rate between 1 month and 6 months(P＞0.999).Based on the outcomes at 6 months,pa-tients were classified into an effective group(n=20)and an ineffective group(n=16).There was no significant differ-ence in gender composition,age,and history of laxative dependence between the two groups(P＞0.05).The course of illness in the ineffective group was longer than that in the effective group,and the difference was statistically significant(P＜0.05).No serious adverse reactions occurred during or after FMT.Mild abdominal pain and bloating occurred in 2 patients(5.6％),and mild diarrhea in 2 other patients,all of which resolved without treatment.Conclusion Oral capsule FMT is effective and safe for the treatment of refractory functional constipation,and its therapeutic effect is related to the course of the disease.
维普
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