2-(甲氧基亚胺基)苯乙酸的合成研究
Study on Synthesis of 2-(Methoxyimino)Phenyl Acetic Acid
孟悦宁 1王彩平 2李飞3
作者信息
- 1. 辽宁石油化工大学 石油化工学院,辽宁 抚顺 113001;大连理工大学宁波研究院,浙江 宁波 315016
- 2. 北京福元医药股份有限公司,北京 101113
- 3. 辽宁石油化工大学 石油化工学院,辽宁 抚顺 113001
- 折叠
摘要
研究了2-(甲氧基亚胺基)苯乙酸即苯基MIA的合成,并对该工艺的反应条件进行了筛选和优化.将甲氧基胺基盐酸盐和碳酸钠固体分别加入圆底烧瓶中,溶于干燥的二氯甲烷,0℃下加入苯甲酰甲酸,25℃下反应 3 h.该工艺方法得到 72%左右的收率,且反应条件简单温和,工艺设备成本廉价,实现了操作简单、经济实惠和绿色环保的目的.
Abstract
The synthesis of 2-(methoxyimino)phenylacetic acid(phenyl MIA)was studied,the reaction conditions of the process were screened and optimized.A solution of methoxy ammonium chloride and Na2CO3 were added to a round-bottomed flask,and then benzoyl formic acid in dry DCM was added at 0℃.The mixture was stirred at 25℃for 3 h.The yield of this process was about 72%,the reaction conditions were simple,mild and the cost of process equipment was cheap.The process method realized the purpose of simple operation,economic benefit and environmental protection.
关键词
甲氧基肟导向基团/碳氢键活化/过渡金属催化/合成Key words
Methoxamine-directed group/C—H bond activation/Transition metal catalysis/Synthesis引用本文复制引用
基金项目
辽宁省重点研发计划(2019JH2/10100005)
出版年
2024
NETL
NSTL
万方数据