首页|9种药食两用药材中15种有机磷类农药残留分析及膳食风险评估

9种药食两用药材中15种有机磷类农药残留分析及膳食风险评估

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对 9 种药食两用药材进行 15 种有机磷类农药残留污染分析和膳食风险评估,为中药材中农药残留快筛方法的开发提供基础数据支持.农药残留采用检出率、超标率进行分析;膳食风险评估分别采用慢性膳食风险评估和急性膳食风险评估.陈皮和栀子检出农药数量最多,共检出8种农药,且 3种为禁用农药;禁用农药中甲拌磷检出最多,在 5 种药材中检出,在当归中检出率高达 100%;限用农药中毒死蜱检出最多,分别在6种中药材中检出,在金银花中检出率高达100%;禁用农药甲拌磷在当归中的超标率高达69.05%,限用农药丙溴磷在陈皮中的超标率为 25.45%.9 种药食两用药材中 15 种有机磷类农药均有不同程度检出,污染现象普遍且超标率较高,虽然目前急性与慢性膳食风险评估结果均在可接受范围内,但农残累积风险加重,势必会对中药材质量造成影响,进而危害人体健康.因此,要科学规范使用农药,并采取有利的监管手段对中药材进行质量控制.
Residue Analysis and Dietary Risk Assessment of 15 Organophosphorus Pesticides in 9 Medicinal and Edible Materials
Pollution analysis and dietary risk assessment of 15 organophosphorus pesticides in 9 medicinal and edible materials were carried out to provide basic data support for the development of rapid screening method for pesticide residues in traditional Chinese medicine.Detection rate and over standard rate were used for pesticide residue analysis.Chronic and acute dietary exposure assessments were calculated for dietary risk assessments.Citri Reticulatae Pericarpium and Gardeniae Fructus had the highest number of pesticides detected,with a total of 8 pesticides detected and 3 of them were prohibited pesticides.Among the banned pesticides,phorate was the most detected,which was detected in 5 traditional Chinese medicine and the detection rate was up to 100%in Angelicae Sinensis.Chlorpyrifos was detected in 6 traditional Chinese medicine,and the detection rate was up to 100%in Lonicerae Japonicae Flos.The over standard rate of the prohibited phorate in Angelicae Sinensis was as high as 69.05%,and the over standard rate of profenofos in Citri Reticulatae Pericarpium was 25.45%.Organophosphorus pesticides in 9 medicinal and edible materials were detected to varying degrees,and the pollution phenomenon was common and the over standard rate was high.Although the current dietary risk assessment results of acute and chronic dietary dietary risk were within the acceptable range,the cumulative risk of pesticide residues was increasing,which would inevitably affect the quality of traditional Chinese medicine and endanger human health.Therefore,it is necessary to scientifically regulate the use of pesticides,and adopt favorable regulatory means to control the quality of traditional Chinese medicine.

Medicinal and edibleTraditional Chinese medicineOrganophosphorus pesticideResidue analysisDietary risk assessment

闫研、梁雪、秦斌、连少敏、王冰、王炳志、殷果

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深圳市药品检验研究院,国家药品监督管理局中药质量研究与评价重点实验室,广东 深圳 518057

深圳市易瑞生物技术股份有限公司,广东 深圳 518101

药食两用 中药材 有机磷类农药 残留分析 膳食风险评估

广东省科技计划

2021A0505080003

2024

当代化工
中国石油抚顺石化公司,中国石化抚顺石油化工研究院,沈阳市医药和化工行业联合会

当代化工

CSTPCD
影响因子:0.412
ISSN:1671-0460
年,卷(期):2024.53(2)
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