乳酸-乙醇酸共聚物(PLGA)制备方法研究进展
Research Progress in Preparation Methods of Lactic Acid-Glycolic Acid Copolymer(PLGA)
李秀峥 1白富栋 1孙启梅 1白毓黎 1张雷 1王鹏翔 1刘来伍1
作者信息
- 1. 中石化(大连)石油化工研究院有限公司,大连市可降解高分子材料重点实验室,辽宁 大连 116045
- 折叠
摘要
作为一种生物可降解聚合物,乳酸-乙醇酸共聚物(PLGA)具有良好的生物可降解性及生物相容性,毒性低,在医疗领域有较高的应用价值,因此对PLGA制备方法的研究具有重要意义.总结了PLGA的制备方法,分别为开环聚合法、直接缩聚法及酶促聚合法,还总结了PLGA的应用,最后对PLGA的研究方向进行了展望.
Abstract
As a biodegradable polymer,lactic acid-glycolic acid copolymer(PLGA)has good biodegradability and biocompatibility,low toxicity,and has high application value in the medical field,which is of great significance to study PLGA preparation method.The preparation methods of PLGA were summarized,including open ring polymerization,direct condensation polymerization and enzymatic polymerization.The application of PLGA was also summarized.Finally,the research direction of PLGA was prospected.
关键词
PLGA/可降解/乙交酯/丙交酯/聚合Key words
PLGA/Degradable/Glycolide/Lactide/Polymerization引用本文复制引用
基金项目
中国石化重点科技项目(总合-062318)
出版年
2024
NETL
NSTL
万方数据