As a biodegradable polymer,lactic acid-glycolic acid copolymer(PLGA)has good biodegradability and biocompatibility,low toxicity,and has high application value in the medical field,which is of great significance to study PLGA preparation method.The preparation methods of PLGA were summarized,including open ring polymerization,direct condensation polymerization and enzymatic polymerization.The application of PLGA was also summarized.Finally,the research direction of PLGA was prospected.