Isolation of Triterpenoids from Fruit of Rosa laevigata Michx.Based on Activity Guidance
The triterpenoids in Rosa laevigata Michx.fruit and their anti-Alzheimer's disease(AD)activities were studied.The neuroprotective was used to guide the isolation.The separation and purification were carried out by silica gel,ODS and reversed-phase HPLC,and the structures were identified by NMR spectroscopy.Eight triterpenoids had high affinity for AChE target proteins,and the inhibition rate was close to that of positive drugs.These results indicated that the triterpenoids had anti-AD activity.
Rosa laevigata Michx.TriterpenoidsActivity guidanceAnti-Alzheimer's disease
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