Synthesis of High Purity 4-Bromo-4'-Propylbiphenyl
Biphenyl liquid crystal has the characteristics of good photoelectric performance and chemical stability,is widely used in the field of instrumentation and display.4-Bromo-4'-propylbiphenyl is an important liquid crystal intermediate,there are some defects in existing related synthesis technologies such as complex steps,high toxicity of original materials and low product purity.In this paper,4-bromobiphenyl was used as the reactant,which reacted with propionyl chloride on the Friedel-Crafts Acylation,and then the final product was obtained by Wolff-Kishner-Huang reduction,and 4-bromo-4'-propylbiphenyl with a purity of more than 99.8%was obtained by recrystallization,the comprehensive yield of the reaction was 21.3%.Based on the results of IR,1H-NMR and MS,the sample was finally identified as 4-bromo-4'-propylbiphenyl.
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