首页|Self-reported Taste and Smell Disorders in Patients with COVID-19:Distinct Features in China

Self-reported Taste and Smell Disorders in Patients with COVID-19:Distinct Features in China

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Last December 2019,a cluster of viral pneumonia cases identified as coronavirus disease 2019(COVID-19)was reported in Wuhan,China.We aimed to explore the frequencies of nasal symptoms in patients with COVID-19,including loss of smell and taste,as well as their presentation as the first symptom of the disease and their association with the severity of COVID-19.In this retrospective study,1206 laboratory-confirmed COVID-19 patients were included and followed up by telephone one month after discharged from Tongji Hospital,Wuhan.Demographic data,laboratory values,comorbidities,symptoms,and numerical rating scale scores(0-10)of nasal symptoms were extracted from the hospital medical records,and confirmed or reevaluated by the telephone follow-up.From patients(n=1172)completing follow-up,199(17％)subjects had severe COVID-19 and 342(29.2％)reported nasal symptoms.20.6％COVID-19 patients had loss of taste(median score=6),while 11.4％had loss of smell(median score=5).Loss of taste scores,but not loss of smell scores,were significantly increased in severe vs.non-severe COVID-19 patients.Interleukin(IL)-6 and lactose dehydrogenase(LDH)serum levels were positively correlated with loss of taste scores.About 80％of COVID-19 patients recovered from smell and taste dysfunction in 2 weeks.In this cohort,only 1 out of 10 hospital admitted patients had loss of smell while 1 out of 5 reported loss of taste which was associated to severity of COVID-19.Most patients recovered smell and taste dysfunctions in 2 weeks.

tastesmellcoronavirus disease 2019severe acute respiratory syndrome coronavirus 2

Jia SONG、Yi-ke DENG、Hai WANG、Zhi-chao WANG、Bo LIAO、Jin MA、Chao HE、Li PAN、Yang LIU、Isam Alobid、De-yun WANG、Ming ZENG、Joaquim Mullol、Zheng LIU

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Department of Otolaryngology-Head and Neck Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

Rhinology Unit and Smell Clinic,ENT Department,Hospital Clinic,IDIBAPS,Universitat de Barcelona,CIBERES,Barcelona 08036,Spain

Department of Otolaryngology,Yong Loo Lin School of Medicine,National University of Singapore 699010,Singapore

This study was supported by grants from the Natural Science Foundation of Hubei Province of ChinaNational Key R&D Program of Chinaand National Natural Science Foundation of Chinaand National Natural Science Foundation of Chinaand National Natural Science Foundation of Chinaand National Natural Science Foundation of China

2018CFB6022018YFC0116800816300248192010801181900925

2021

10.1007/s11596-021-2312-7

当代医学科学(英文)
同济医科大学

当代医学科学(英文)

SCI
ISSN：2096-5230
年,卷(期)：2021.41(1)
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