首页|Differences in Immune Responses between Children and Adults with COVID-19
Differences in Immune Responses between Children and Adults with COVID-19
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Over 85 590 000 individuals have been infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Although there have been an increasing number of reports on coronavirus disease 2019(COVID-19),it is unclear why infected children show milder symptoms than adults.A retrospective case study was performed at two designated hospitals for COVID-19.Patients(56 children and 63 adults)with confirmed SARS-CoV-2 infection and mild pneumonia were randomly enrolled in this study.The median age of the children was 7.0 years,and 51.79％of them were boys.The median age of the adults was 57 years,and 47.62％were men.The most common symptoms were fever,cough,sputum and diarrhoea.There were no significant differences in symptoms between children and adult patients.In terms of immunological indices on admission,adult patients displayed typical leukopenia and markedly higher levels of IL-2,IL-4,and IL-6 than child patients.The elevation of IL-2,IL-4 and IL-6 in adults induced more extensive lung injury.The effective and non-aggressive immune response successfully resisted SARS-CoV-2 invasion and maintained mild symptoms in child patients.The correlation of higher IL-2,IL-4,and IL-6 with the lung injury might be evidence that preventing excessive cytokine production can avoid further lung damage in these patients.
COVID-19childadultimmune response
Yin YUAN、Qiu-peng WANG、Dan SUN、Zu-bo WU、Hua PENG、Xin-wen LIU、Ya-ling LIU
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Department of Pediatrics,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China
Department of Neurology,Wuhan Children's Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430015,China
This project was supported by the Hubei Natural Science Foundation of China
NETL
NSTL
万方数据
维普
