首页|Expression of α2-Na/K-ATPase in C57BL/6J Mice Inner Ear and Its Relationship with Age-related Hearing Loss

Expression of α2-Na/K-ATPase in C57BL/6J Mice Inner Ear and Its Relationship with Age-related Hearing Loss

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K+cycling in the cochlea is critical to maintain hearing.Many sodium-potassium pumps are proved to participate in K+cycling,such as Na/K-ATPase.The α2-Na/K-ATPase is an important isoform of Na/K-ATPase.The expression of α2-Na/K-ATPase in the cochlea is not clear.In this study,we used C57BL/6 mice as a model of presbycusis and implemented immunohistochemistry staining and quantitative real time-PCR,and the α2-Na/K-ATPase expression pattern was confirmed in the inner ear.It was found α2-Na/K-ATPase was expressed widely in cochlea and its mRNA and protein expression was gradually reduced with aging(4-,14-,26-and 48-weeks old mice).We suspected that,the down-regulation of α2-Na/K-ATPase expression might be associated with the remodeling of K+cycling,degeneration of morphological structure and decrease of hearing function in aging C57 mice.In conclusion,we speculated that the reduction of α2-Na/K-ATPase might play an important role in the pathogenesis of age-related hearing loss.

α2-Na/K-ATPaseC57BL/6J mouseinner earage-related hearing lossK+cycling

Yun LIU、Han-qi CHU、Yan-bo SUN、Dan BING、Liang-qiang ZHOU、Jin CHEN、Qing-guo CHEN、Zhi-hui DU

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Department of Otolaryngology-Head and Neck Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

Department of Otolaryngology-Head and Neck Surgery,the Central Hospital of Wuhan,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

This study was supported by National Natural Science Foundation of ChinaThis study was supported by National Natural Science Foundation of ChinaThis study was supported by National Natural Science Foundation of ChinaThis study was supported by National Natural Science Foundation of ChinaThis study was supported by National Natural Science Foundation of China

Nos.8177100481271078815007918150079481300827

2021

10.1007/s11596-021-2330-5

当代医学科学(英文)
同济医科大学

当代医学科学(英文)

SCI
ISSN：2096-5230
年,卷(期)：2021.41(1)
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