首页|Shear Wave Elastography of Invasive Ductal Carcinoma:Correlations between Shear Wave Velocity and Histological Prognostic Factors

Shear Wave Elastography of Invasive Ductal Carcinoma:Correlations between Shear Wave Velocity and Histological Prognostic Factors

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The correlations between shear wave velocity(SWV)calculated from virtual touch tissue imaging quantification(VTIQ)technique and histological prognostic factors of invasive ductal carcinoma was investigated.A total of 76 breast tumors histologically confirmed as invasive ductal carcinomas were included in this study.SWV values were measured by VTIQ for each lesion preoperatively or prior to breast biopsy.The maximum values were recorded for statistical analysis.Medical records were reviewed to determine tumor size,histological grade,lymph node status and immunohistochemical results.Tumor subtypes were categorized as luminal A,luminal B,human epidermal growth factor receptor 2(HER2)positive and triple negative.The correlations between SWV and histological prognostic factors were analyzed.It was found that tumor size showed positive association with SWV(r=0.465,P＜0.001).Larger tumors had significantly higher SWV than smaller ones(P=0.001).Histological grade 1 tumors had significantly lower SWV values than those with higher histological grade(P=0.015).The Ki67 expression,tumor subtypes and lymph node status showed no statistically significant correlations with SWV,although triple negative tumors and lymph node-positive tumors showed higher SWV values.It was concluded that tumor size was significantly associated with SWV.Higher histological grade was associated with increased SWV.There was no statistically significant correlations between SWV and other histological prognostic factors.

shear wave elastographyvirtual touch tissue imaging quantificationshear wave velocityinvasive ductal carcinomahistological prognostic factors

Xiao-qing HU、Li PENG、Max Wintermark、Jafi Alyssa Lipson、Yan-rong ZHANG、Yuan GAO

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Department of Ultrasound,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China

Hubei Key Laboratory of Molecular Imaging,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China

Department of Pathology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China

Department of Radiology,Neuroradiology Section,Stanford University,Palo Alto,California,USA

Department of Radiology,Stanord University,Palo Alto,California,USA

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This project was supported by grants from the Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central UniversitiesNational Natural Science Foundation of Chinaand Hubei Key Laboratory of Molecular Imaging Research Funds

2172015YGYL0192015LC0218100061602.03.2015-149

2021

10.1007/s11596-021-2333-2

当代医学科学(英文)
同济医科大学

当代医学科学(英文)

SCI
ISSN：2096-5230
年,卷(期)：2021.41(1)
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