首页|Ovarian Toxicity and Epigenetic Mechanisms of Phthalates and Their Metabolites

Ovarian Toxicity and Epigenetic Mechanisms of Phthalates and Their Metabolites

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Ovary plays an important role in the female reproductive system.The maintenance and regulation of ovarian function are affected by various physical and chemical factors.With the development of industrialization,environmental pollutants have caused great harm to public health.Phthalates,as a class of endocrine-disrupting chemicals (EDCs),are synthesized and used in large quantities as plasticizers due to their chemical properties.They are easily released into environment because of their noncovalent interactions with substances,causing human exposure and possibly impairing ovary.In recent years,more and more attention has been paid to the role of epigenetics in the occurrence and development of diseases.And it is urgent to study the role of methylation,gene imprinting,miRNA,and other epigenetic mechanisms in reproductive toxicology.

epigeneticsmethylationmiRNAsovarian toxicityphthalatesreproductive health

Hua-hua JIANG、Yao-yao DU、Yu-feng LI

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Reproductive Medical Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Youth Foundation of ChinaSelf-dependent Innovation Research Funding of Huazhong University of Science and Technology

8157150881771654817015202017KFYXJJ121

2021

10.1007/s11596-021-2342-1

当代医学科学(英文)
同济医科大学

当代医学科学(英文)

SCI
ISSN：2096-5230
年,卷(期)：2021.41(2)
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