Rapid Establishment of Tracheal Stenosis in Pigs Using Endotracheal Tube Cuff Overpressure and Electrocautery

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外文摘要：To apply a new airway treatment to humans,preclinical studies in an appropriate animal model is needed.Canine,porcine and leporine tracheas have been employed as animal airway stenosis models using various methods such as chemical caustic agents,laser,and electrocautery.However,existing models take a long time to develop (3-8 weeks) and the mechanism of stenosis is different from that in humans.The aim of the present study was to establish a new and fast tracheal stenosis model in pigs using a combination of cuff overpressure intubation (COI) and electrocautery.Fourteen pigs were divided into three groups: tracheal cautery (TC) group (n=3),COI group (n=3),and COI-TC combination group (n=8).Cuff overpressure (200/400/500 mmHg) was applied using a 9-mm endotracheal tube.Tracheal cautery (40/60 watts) was performed using a rigid bronchoscopic electrocoagulator.After intervention,the pigs were observed for 3 weeks and bronchoscopy was performed every 7 days.When the cross-sectional area decreased by ＞ 50％,it was confirmed that tracheal stenosis was established.The time for tracheal stenosis was 14 days in the TC group and 7 days in the COI-TC combination group.In the COI group,no stenosis occurred.In the COI-TC group,electrocautery (40 watts) immediately after intubation for ＞ 1 h with a cuff pressure of 200 mmHg or more resulted in sufficient tracheal stenosis within 7 days.Moreover,the degree of tracheal stenosis increased in proportion to the cuff pressure and tracheal intubation time.The combined use of cuff overpressure and electrocautery helped to establish tracheal stenosis in pigs rapidly.

外文关键词：

pig tracheal stenosis modelcuff overpressureelectrocautery

作者：

Jin Hyoung Kim、Jong Joon Ahn、Yangjin Jega、Soohyun Bae、Soon Eun Park、Moon Sik Jung、Ju Ik Park、Hee Jeong Cha、Yongjik Lee、Taehoon Lee

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作者单位：

Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 44033, Korea

Department of Anesthesiology and Pain Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 44033, Korea

Department of Pathology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 44033, Korea

Department of Thoracic and Cardiovascular Surgery, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 44033, Korea

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基金：

study was funded by the National Research Foundation of Korea

项目编号：

NRF-2017R1C1B5076493

出版年：

2021

DOI：

10.1007/s11596-021-2351-0